Dive into the heart of New Orleans with homemade Muffuletta Bread, the ultimate foundation for the renowned Louisiana sandwich. This golden, sesame seed-studded loaf is as beautiful as it is delicious, featuring a soft, fluffy interior and just the right amount of crusty chew. Made with pantry-friendly ingredients like all-purpose flour, olive oil, and active dry yeast, and topped with fragrant sesame seeds, this bread's subtle richness pairs perfectly with the bold flavors of a traditional muffuletta filling. Whether you're crafting an authentic sandwich or serving it alongside your favorite spreads, this recipe is an easy, satisfying way to bring a taste of the Big Easy into your kitchen. Ready in just a few hours with simple, step-by-step instructions, it's a must-try for bread enthusiasts and food lovers alike.
In a large bowl, combine the warm water and sugar. Stir until the sugar dissolves, then sprinkle the active dry yeast over the water. Let it sit for 5–10 minutes or until the mixture becomes frothy.
Add 2 cups of the all-purpose flour, salt, and olive oil to the yeast mixture. Stir with a wooden spoon or spatula until well combined.
Gradually add the remaining 2 cups of flour, about 1/2 cup at a time, mixing until the dough starts to come together.
Turn the dough onto a lightly floured surface and knead for 8–10 minutes, or until it is smooth and elastic. Add a small amount of flour as needed to prevent sticking.
Place the dough in a lightly oiled bowl, turning it to coat the surface with oil. Cover the bowl with a clean kitchen towel or plastic wrap and let the dough rise in a warm place for 1 hour, or until it doubles in size.
Punch down the dough to release air bubbles. Shape it into a round or oval loaf and place it on a baking sheet lined with parchment paper.
Cover the shaped dough with a towel and let it rise again for 30–40 minutes, or until it puffs up slightly.
Preheat your oven to 375°F (190°C). Brush the top of the dough with a bit of water and sprinkle generously with sesame seeds.
Bake the bread in the preheated oven for 20–25 minutes, or until the top is golden brown, and the bread sounds hollow when tapped on the bottom.
Let the bread cool completely on a wire rack before slicing and using to make your Muffuletta sandwich or serving as desired.
Serving size | 862.7 grams (862.7g) |
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Amount per serving | % Daily Value* |
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Calories | 2282 |
Total Fat 56.90g | 73% |
Saturated Fat 8.70g | 43% |
Polyunsaturated Fat 8.10g | |
Cholesterol 0mg | 0% |
Sodium 3560mg | 155% |
Total Carbohydrate 379.30g | 138% |
Dietary Fiber 16.40g | 59% |
Total Sugars 9.50g | |
Protein 55.60g | 111% |
Vitamin D 0IU | 0% |
Calcium 78mg | 6% |
Iron 24mg | 132% |
Potassium 718mg | 15% |
Source of Calories