Get ready to elevate your weeknight dinner game with this irresistible Meatloaf Enchilada Casserole—a mouthwatering fusion of classic comfort food and bold Tex-Mex flavors. This hearty casserole layers a seasoned blend of ground beef and pork, rich enchilada sauce, tender corn tortillas, and gooey cheddar cheese for a dish that’s as satisfying as it is flavorful. The addition of diced green chilies and aromatic spices like cumin and chili powder adds just the right amount of zest, while the golden-brown cheesy topping ensures every bite is indulgent. Ready in just over an hour and perfect for feeding a family, this layered casserole is easy to prepare and ideal for leftovers. Garnish with fresh cilantro and a dollop of creamy sour cream to complete your Tex-Mex masterpiece! Perfect keywords: enchilada casserole recipe, Tex-Mex meatloaf, easy family dinner, layered beef casserole.
Preheat your oven to 375°F (190°C) and grease a 9x13-inch casserole dish.
In a large bowl, combine the ground beef, ground pork, onion, garlic, egg, panko bread crumbs, 1/2 cup of enchilada sauce, cumin, chili powder, salt, and black pepper. Mix until thoroughly combined.
Spread half of the meat mixture evenly across the bottom of the prepared casserole dish, pressing it down to form a flat layer.
Place 4 corn tortillas on top of the meat layer, slightly overlapping if necessary.
Spread half of the remaining enchilada sauce over the tortillas, then sprinkle with 1 cup of shredded cheddar cheese and half of the diced green chilies.
Add the remaining meat mixture on top, spreading it out to cover the filling layers.
Place the remaining 4 tortillas over this second meat layer, spread the remaining enchilada sauce on top, and sprinkle with the remaining shredded cheddar cheese and green chilies.
Cover the dish with aluminum foil and bake in the preheated oven for 30 minutes.
Remove the foil and bake for an additional 15-20 minutes, or until the cheese is bubbly and golden brown.
Let the casserole rest for 10 minutes before slicing. Garnish with chopped cilantro and serve with sour cream, if desired.
Serving size | 2212.1 grams (2212.1g) |
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Amount per serving | % Daily Value* |
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Calories | 4155 |
Total Fat 245.40g | 315% |
Saturated Fat 114.70g | 574% |
Polyunsaturated Fat 3.00g | |
Cholesterol 1027mg | 342% |
Sodium 7453mg | 324% |
Total Carbohydrate 251.20g | 91% |
Dietary Fiber 30.90g | 110% |
Total Sugars 28.60g | |
Protein 241.10g | 482% |
Vitamin D 54IU | 269% |
Calcium 2404mg | 185% |
Iron 25mg | 141% |
Potassium 3268mg | 70% |
Source of Calories